Ignacio

Principal Investigator, Associate Professor

Ignacio Saez, PhD

Icahn School of Medicine at Mount Sinai (ISMMS)
Department of Neuroscience, Department of Neurosurgery, Department of Neurology, Friedman Brain Institute
Director, Laboratory for Human Neurophysiology

LinkedIn.PubMed.Bluesky link.
Ignacio Saez.

A lifetime of exploration

Ignacio Saez, Ph.D. is an Associate Professor in the Departments of Neuroscience, Neurosurgery, and Neurology and the Director of the Human Neurophysiology Laboratory at the Icahn School of Medicine at Mount Sinai and the Friedman Brain Institute. His research focuses on understanding how human cognition arises from the interaction of multiple brain areas and neurotransmitter systems, particularly in decision-making behavior. Dr. Saez's research involves studying prefrontal cortical and subcortical areas directly in the human brain by conducting intracranial electrophysiology recordings in patients undergoing neurosurgical treatment.

Dr. Saez aims to provide a more comprehensive understanding of the neurobiological basis of human decision-making behavior, which could lead to the development of novel neurotherapeutic approaches for psychiatric conditions, such as depression. Prior to his current position, Dr. Saez was an Assistant Professor at the UC Davis Center for Neuroscience and completed his postdoctoral work at the University of California, Berkeley, Haas School of Business, and Virginia Tech. He earned his Ph.D. from Baylor College of Medicine.

Professional Appointments & Affiliations

2024
-
Present
Associate Professor
,
Icahn School of Medicine at Mount Sinai (ISMMS) Department of Neuroscience, Department of Neurosurgery, Department of Neurology, Friedman Brain Institute
2021
-
2023
Assistant Professor
,
Icahn School of Medicine at Mount Sinai (ISMMS) Department of Neuroscience, Department of Neurosurgery, Department of Neurology, Friedman Brain Institute
2019
-
Present
Advisory Board Member
,
Fundacion Tatiana Perez de Guzman el Bueno, Madrid, Spain
2018
-
2021
Assistant Professor
,
University of California, Davis Department of Neurological Surgery, Center for Neuroscience
2019
-
2020
Co-Director
,
Postdoctoral Career Development Seminar Series, UC Davis
2017
-
2019
Co-Director
,
Postdoctoral Career Development Seminar Series, UC Berkeley
Affiliations
Lipschultz Center for Cognitive Neuroscience
Computational Psychiatry Center
Center for Advanced Therapeutics
Friedman Brain Institute

Education

2013
-
2018
Postdoctoral Researcher
,
University of California, Berkeley
Department of Neuroscience
Advisors:
Drs. Robert T. Knight and Ming Hsu
Topic:
Multi-areal human intracranial recordings during decision-making
2010
-
2012
Postdoctoral Researcher
,
Virginia Tech
Department of Neuroscience
Advisors:
Dr. P. Read Montague
Topic:
Sub-second dopamine measurements in the human brain during decision-making
2003
-
2010
PhD, Neuroscience & Postdoctoral Researcher
,
Baylor College of Medicine
Department of Neuroscience
Advisors:
Dr. Michael J. Friedlander
Topic:
Properties and plasticity of unitary connections between neuronal pairs in visual cortex
2002
-
BS, Clinical and Molecular Biology
,
University of Navarra, Pamplona, Spain
Advisors:
Topic:
2001
-
BS, Biochemistry
,
University of Navarra, Pamplona, Spain
Advisors:
Topic:

Awards, Honors, and Recognitions

2023
-
One Mind–Russ and Stephanie Deyo Rising Star Award
2020
-
Edwin Boldrey Award, San Francisco Neurological Society
2013
-
2015
Dean’s Office Award, UC Berkeley, Haas School of Business
2011
-
Travel Award, National Institute on Drug Abuse
2003
-
2005
Fellowship for Postgraduate Studies, La Caixa Foundation
2002
-
2003
Marie Curie Fellowship, European Union

Invited Talks and Seminars

2023
Developing personalized therapies for treatment-resistant depression

One Mind Science and Innovation Symposium

2023
Intracranial recordings of value: leveraging intracranial interventions for cognitive neuroscience research

Rutgers-Princeton Center for Computational Cognitive Neuropsychiatry
Department of Psychiatry, Columbia University

2022
Leveraging intracranial interventions for cognitive neuroscience research

Friedman Brain Institute Retreat, ISMMS

2021
Basic neuroscience research in clinical settings: leveraging invasive interventions

Grand Rounds, Department of Neurology, ISMMS

2021
Neuroeconomía: cómo nuestro cerebro decide por nosotros

Fundación Tatiana Pérez de Guzmán el Bueno, Madrid, Spain

2020
Studying and modulating human decision-making with invasive recordings

Center for Mind and Brain Kickoff Meeting, UC Davis

2019
Unveiling the computational substrates of human decision-making with intracranial recordings

Biological psychology seminar series, Department of Psychology, UC Davis

2018
Neuroeconomics: insights into the neural basis of human decision-making

Behavioral economics seminar series, Department of Economics, UC Davis

2018
Research in functional neurosurgery: unveiling the neurobiological basis of human cognition

Neurology Research Forum, UC Davis

2018
Research in functional neurosurgery: unveiling the neurobiological basis of human cognition

1st Annual Wagner Symposium, UC Davis
Neuroscience Graduate Bootcamp, UC Davis

2017
Estudiando las bases neurofisiológicas de la toma de decisiones con registros intracraneales

University of Navarre, Pamplona, Spain

2016
Fast value-based computations in the human brain revealed by intracranial recording techniques

Cognitive Neuroscience Colloquium Series, UC Berkeley

2016
Coordinated activation of value-related computations across human orbitofrontal cortex

HWNI Retreat, UC Berkeley

2016
Fast value-based computations in the human brain revealed by intracranial recording techniques

UC Davis
Basque Center on Cognition and Language, San Sebastian, Spain
Academic Medical Center, Amsterdam, Netherlands
PsychoEconomics workshop, DFG Research Unit, Konstanz, Germany
Bonn University, Bonn, Germany
Otto-von-Guericke University, Magdeburg, Germany
Clinical University Hamburg-Eppendorf, Hamburg, Germany
University Aix Marseille, Marseille, France

2014
Molecular and genetic bases of human social behavior

UC Berkeley

2014
A pathway analysis approach to the study of the genetic basis of decision-making

National University of Singapore, Queenstown, Singapore
Nanyang Technological University, Singapore

2014
Genetic and neurochemical basis of pro-social decision making

Institute for Integrative Social Sciences, UC Berkeley

2013
Sub-second measurements of dopamine concentration in the human brain

Department of Neurosurgery, UCSF

2012
Sub-second measurements of dopamine concentration during deep-brain stimulation

Neuroscience School for Advanced Studies, Tuscany, Italy

2008
Properties and plasticity of connections within visual cortex layer

Brain Research Institute, Zürich, Switzerland

2007
Plasticity of synaptic connections in visual cortex layer 4

9th Rush Record Symposium, Galveston, TX

2006
Synaptic outputs of individual layer 4 neurons in guinea pig visual cortex

8th Rush Record Symposium, Galveston, TX

Teaching Experience

2023
-
Lecturer
,
Neuro Core Unit 3: Behavioral and Cognitive Neuroscience Graduate Course, Lectures: Value & Flexibility in Decision-making, ISMMS
2018
-
2020
Instructor of Record
,
Design to Data: Statistics for Modern Neuroscience Graduate Course, UC Davis
2019
-
2020
Co-Director
,
Postdoctoral Career Development Seminar Series, UC Davis
2017
-
2019
Co-Director
,
Postdoctoral Career Development Seminar Series, UC Berkeley
2019
-
Director
,
1st Fieldtrip Bootcamp for Analysis of iEEG Data, UC Davis
2017
-
2018
Instructor
,
Clinical Neuroscience Undergraduate Course, Decision-Making Section, UC Berkeley
2017
-
Instructor
,
Neuropsychology Undergraduate Course, Decision-Making Section, UC Berkeley
2006
-
2008
Teaching Assistant
,
Introduction to Methods in Neuroscience Graduate Course, Baylor College of Medicine

Professional Roles and Memberships

Professional Roles

Institutional Service
Institutional Service
2022
-

Co-Chair, Faculty Search Committee, Friedman Brain Institute, ISMMS

Institutional Service
2022
-
pres.

Mentor, Women in Science, ISMMS

Institutional Service
2022
-
pres.

Member, Postdoc Advisory Committee (PAC), ISMMS

Institutional Service
2020
-
2021

Co-Chair, Faculty Search Committee, Department of Neurology, UC Davis

Institutional Service
2020
-
2021

Member, Faculty Search Committee, Center for Neuroscience and Department of Neurology, UC Davis

Institutional Service
2020
-

Member, Faculty Search Committee, Department of Neurological Surgery, UC Davis

Institutional Service
2018
-
2021

Member, Neuroengineering and Medicine Steering Committee, UC Davis

Grant Review
Grant Review
2023

NIH Study Section, Targeted BRAIN Circuits Projects (R01)

Grant Review
2023

NIH Study Section, ZRG1 Sensory and Motor Neurosciences, Cognition and Perception (F30/F31/F32)

Grant Review
2022

NIH Study Section, Behavioral Neuroscience (F02A)

Grant Review
2021

NIH Study Section, BRAIN Initiative NRSA (F32)
NIH Study Section, HCMF (Human Complex Mental Function)

Journal Review
Journal Review
Ad Hoc
-

Nature Neuroscience, Neuron, Nature Human Behavior, Nature Communications, Journal of Neuroscience, Cerebral Cortex, Neuroscience, Journal of Neurophysiology, PLoS One, Neuropsychopharmacology, Micromachines, European Journal of Neuroscience, Biological Psychiatry

Other Service
Other Service
2019
-
pres.

International Advisory Board, Centro Internacional de Neurociencia y Ética (CINET), Fundación Tatiana Pérez de Guzmán el Bueno, Madrid, Spain

Other Service
2018
-
pres.

Editorial Board, Frontiers in Neuroscience

Memberships

Biological Psychiatry Society
Society for Neuroeconomics
Human Brain Mapping Organization
American Association for the Advancement of Science
Cognitive Neuroscience Society
Society for Neuroscience
Federation of European Neuroscience Societies

Press Highlights

The findings published today confirmed observations made with imaging techniques.

A macroproject publishes a brain atlas, a map for understanding what makes us human

El País
,
October 13, 2023
Ignacio Saez, right, and two other men discuss computational psychiatry.

Treating depression through computational psychiatry

Ignacio Sáez in a stairwell.

Ignacio Sáez, neurocientífico: “Nuestra capacidad de prever el futuro y revisar el pasado nos predispone a la enfermedad mental”

El País
,
September 6, 2023

Aspen Ideas Festival – Ignacio Saez, PhD

Man speaking with video button in the middle.

¿Puede ser provechoso el diálogo entre la neurociencia y la filosofía?

Man crossing his arms and smiling in a lab, in front of a microscope.

¿Un fármaco para ser más justos?

La Rioja, Spain
,
May 10, 2015
Hand holding a single pill.

There Could Soon Be a Pill to Make Us More Compassionate

Time Magazine
,
March 21, 2015